2 – 7 The mean age of diabetic patients is decreasing, and the incidence of diabetes in children is increasing worldwide. 2 Previous studies on diabetic populations in hospitals and communities revealed that the prevalence of DE in patients with diabetes was significantly higher than in the general population. 1 DE may cause ocular discomfort, such as dryness, foreign body sensation, eye pain, vision fluctuations, and even serious consequences including secondary bacterial infections, scarring, and corneal perforations. Our findings found high similarities in the pathogenesis of diabetic DE in adults and children.ĭiabetic dry eye (DE), which greatly reduces the quality of life of patients with diabetes, is a common condition treated in healthcare outpatient departments. The differentially expressed tear proteins in type 2 diabetes of adults and children was associated with inflammation, immune factors, and lipid metabolism. The pathogenesis of diabetic DE was highly similar in adults and children. Kyoto Encyclopedia of Genes and Genomes analysis found similarities among metabolic pathways involved in differential expression of proteins in adult and child tear samples. For children, 2709 proteins were identified, and WGCNA analysis identified one hub gene related to diabetic DE. In adults, 1922 proteins were identified, and WGCNA analysis revealed three hub genes related to diabetic DE. Tear film function was poorer in patients with diabetic DE. We extracted total proteins and labeled them with TMTs for analysis. The adult groups included diabetics with DE (A), diabetics without DE (B), and normal controls (C) the corresponding groups of children were identified as (D), (E), and (F). Study subjects were divided into six groups of 10, including three groups each for adults and children. We used tandem mass tag (TMT)–labeled proteomics and weighted correlation network analysis (WGCNA) to identify differentially expressed proteins in the tear proteome of adults and children with diabetic DE. The ages of diabetes are decreasing, so ocular surface status in younger generations is worthy of attention. ![]() Diabetics are more prone to suffer from dry eye (DE).
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